Osteoporosis is defined as a loss of bone density and changes to bone architecture resulting from age-related hormone deficiency. During adulthood bone is continually remodeled through the resorption of old bone by osteoclasts and the subsequent formation of new bone by osteoblasts. Osteoporosis results from an imbalance between bone resorption and bone formation, leading to bone loss, which, over the years, leads to a loss of the structural integrity of bone and an increased risk of fracture.
According to the National Osteoporosis Foundation (NOF):
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